We all know that CSC (Cancer stem cell) are germ line of tumor giving rise to body of tumor cell. Then why this body of tumor cell fails to carry single gene mutation or single gene alteration, that first arise in pre-cancerous CSCs.
Imagine a condition where I activate one proto-oncogene (RAS) in NSC(clonal Normal stem cell) and injecting it in NOD/SCID mice to give rise to bulk tumor. Later When we do gene expression/mutational study in this bulk tumor, we won’t find RAS gene alteration in every tumor cell within this bulk tumor, Why it so ?
Does it mean bulk tumor is formed not only from clonal normal stem cell that carries single aberrant gene(RAS). (Or) Will there is any chance for the mutation (RAS) to be corrected (De novo/naturally ) after few doublings of clonal Normal stem cell/CSC.
You may be confused with the following terms;
driver mutation
passenger mutation
tumor-initiating cells (= cancer stem cells)
stemness
Why not read the following review????
Article Therapeutic Strategies Targeting Cancer Stem Cells
Thanks Dr.Yoshida.. Will read the review and will get back to you if i have any doubts ..
Dear Friends,
I have published a paper recently.
it shows the attitude of stem cells researchers.
All the best!
Mahdi.
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