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Questions related from Suresh Oncosuresh
I am treating populations A and B with drug X and with drug Y. I get a significant difference in response to drug X between populations A and B via the Mann Whitney U test. Meanwhile, there is no...
29 March 2022 2,367 2 View
In the attached figure, treated (T) versus Control (C). the box plot in control (C) shows the overlap of the lower quartile with the minimum value. Does this boxplot (c) make sense ? is it...
29 March 2022 530 2 View
Is it possible to attain IC50 if my target cells have less than 50% antigen expression ? For example: Cancer cell line XXX is showing 35% of expression of cell surface antigen YYYY, if i...
05 February 2021 3,099 3 View
I have transfected a cell with a bicistronic vector "Gene of interest and GFP" for transient expression in HEK293T. The cells are transfected successfully, as they continue to survive in Zeocin...
11 July 2020 3,967 0 View
Hi All. I am using 4 different plasmid, each encoding different scFv with similar back bone, The only difference between all the plasmid is nucleotide encoding for scFv seq (Antibody Seq)....
19 February 2019 7,221 12 View
Can Chemo drug elicit abscopal effect ? & Lysing (In Vitro) surgically excision tumor and admitting it back to the same patient who has multiple metastasis , will elicit abscopal effect ?
12 February 2017 3,667 1 View
We know during diagnosis of leukemia (B-ALL,T-ALL) , leukemia Blast cells are seen in BM (20% and above) and Peripheral Blood (10% and above). We know this free floating blast that is seen in...
01 February 2017 5,432 0 View
Here is an example : concentration Average Percentage viability in normal cell line 0.1 1001 98.2310 ...
07 September 2016 1,554 3 View
We know CD4, CD8, NK Cell secrete cytotoxic granules like perforin and granzyme A,B etc to remove viral and or pathogen infected cell .. Will any epithelial or non-immune cell secrete cytotoxic...
17 July 2016 2,960 1 View
Consider this scenario, where 35 year old female is diagnosed for breast cancer (malignant), her Breast tumor is completely dissected from her breast or body via mastectomy or lumpectomy. Later...
28 June 2016 1,109 2 View
Why familial mutation in RB gene prefer to give rise to Retinoblastoma, why not other type of cancer ? (or) Why familial BRCA gene prefer to give rise to Breast cancer, why not other type of...
23 June 2016 7,927 3 View
1) Which one of the following has increased risk of becoming tumor ? A) Cells with shortest doubling time (often divide) and shortest life span. B) Cells with longest doubling time (rarely divide)...
09 June 2016 8,831 1 View
We all know that CSC (Cancer stem cell) are germ line of tumor giving rise to body of tumor cell. Then why this body of tumor cell fails to carry single gene mutation or single gene alteration,...
02 June 2016 5,845 3 View
On nature ,it should be mandatory that CAD has to cleave the DNA for every 180bp .. But from DNA Ladder assay ,we know that we have many stacking .as DNA is not uniformly cleaved at every 180bp...
27 July 2015 3,108 1 View
The failure of 180bp uniform cleavage in cancerous apoptotic cell, is clear with DNA fragmentation assay. Suppose by chance abberant gene in cancerous apoptotic cell get intercalate with...
27 July 2015 9,355 6 View
Will ALL acute lymphoblastic leukemia T lymphocyte/B lymphocytes protect themselves from foreign substances (Microbes) in cancer patients? If Yes, how will they do this? Being immature cells, how...
21 July 2014 7,762 5 View
We human migrate from one place to another, when we could not able to find the basic needs like water shelter, food. But why cancer cell has to migrate from its place of origin?We know how and...
20 September 2013 7,254 11 View
Dendritic cell present antigenic peptide to CD4+Tcell or CTLs and activate them to kill tumor cell or viral infected cell ,which is specific to the antigen presented by Dendritic cell .. My...
03 October 2011 6,479 29 View
