Hello researcher
I'm trying to develop a new method to determine the global DNA methylation , and now I'm going to test this method , I'm looking for, if there is a certain organism that have a narrow range of variation in its DNA methylation to use its DNA for quality control ?
Dear Hayder,
Tables 1 and 2 in the publication contained in the attached file may be helpful.
Hoping this will be helpful,
Rafik
Dear
In definition: DNA methylation is one of the most studied epigenetic mechanisms modulating gene expression and has important health implications. For example, the gain or loss of DNA methylation can produce loss of genomic imprinting and results in diseases such as Beckwith-Wiedemann, Prader-Willi, and Angelman syndromes.
You can find more details in the following publication: Cross-Species Analysis of Genic GC3 Content and DNA Methylation Patterns.Tatiana Tatarinova,1, Eran Elhaik and Matteo Pellegrin. Genome Biol Evol. 2013; 5(8): 1443–1456.
Also some databases available are: TAIR version 7 for Arabidopsis thaliana; BeeBase (www.beebase.org) annotation for Apis mellifera; NCBI GenBank for Homo sapiens (hg18); and dmel_hetr31 from FlyBase (www.flybase.org)
Good luck
Marius
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