I dissove Tacrolimus in DMSO and it gets absorbed and Tacrolimus is found in blood in safe levels. I want to know where exactly Tacrolimus act in the urinary bladder.
Hello Dr Mishra,
Is this paper of any help? Initially see Figure 1:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708561/figure/f1/
Janicki, J. J., Gruber, M. A., & Chancellor, M. B. (2015). Intravesical liposome drug delivery and IC/BPS. Translational andrology and urology, 4(5), 572.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708561/
Very best wishes,
Mary
I have gone through this paper. I use DMSO to dissolve tacrolimus. Tacrolimus gets absorbed with DMSO. it might be decreasing inflammation in bladder. Thanks for input.
'm transplanting as a transplanting organ immunologist and all the answers will be very useful in my daily work!
Tacrolimus is calceneurin inhibitor. Do you think it works in the same way in bladder as in renal transplants?
Tacrolimus Prograf FK-506, together with Cclosporine, is a basic immunosuppressive inhibitor of T helper auxiliary cells and prevents the formation of IL-2 as triggers, ie to stop the immune response at that level before generating CD3, CD4, CD8 subpopulations responsible for rejection. It is given to kidney transplantation, especially the liver, where it is most often the main drug like immunosuppressive! That's part of the Calcineurin inhibitor group, like Cyclosporin, and it's all over the body!
The concentration of Tacrolimus will be more in bladder cells and it can have a direct effect before it reaches blood and acts as calcenurin inhibitor.
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