Immunosuppressive therapies can have various effects on fertility outcomes, both directly and indirectly. Here's an overview of how immunosuppressive therapies can impact fertility, as well as the potential risks and benefits associated with their use in infertility treatments:
Direct Effects on Fertility:
Some immunosuppressive drugs, such as cyclophosphamide and methotrexate, are known to have gonadotoxic effects, meaning they can damage the ovaries or testes, leading to impaired fertility or sterility.
Indirect Effects on Fertility:
Immunosuppressive therapies can increase the risk of infections, including sexually transmitted infections (STIs), which may adversely affect fertility.