I heard most brain cancer cells avoid t-cells very well, but is there a cell line (human or animal) that is a little more vulnerable to T-cells than others?
thanks!
Gloria
Dear Gloria,
This link helps you:
http://www.braintumortreatment.com/clinical-trials/brain-tumor-research/brain-tumor-research.aspx
Dear Gloria,
You should work in vitro with a GBM cell line that is compatible in vivo with a syngeneic model. Here attached you have an article that could be of help for you.
I do not think that data generated in vitro with human glioma cells and human T-cells will be easy to be further validated in vivo using immunocompromized mice (nude mice / athymic mice) or even SCID mice.
Best regards
Robert
Dear Gloria
Brain, (as well as testis), as I remember, is an immune sanctuary. Nature has designed it so because any attack by even body's own immune cells, which kill to-be-malignant cells in other parts; killing off brain cells is not a solution. Brain cells, I mean nerve cells, are functional and do not divide; if they divide, the already established connections will be lost. To speculate, immune cells may stimulate them to divide and this also is harmful. It is possible that GM cells are probably astrocytomas that were stimulated to divide in an accelerated sort of way by infiltrating T-cells, it is possible that such GM cells are the ones that showed 'affinity' for T-cells!
Narayanan
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