Just wondering what are the features that makes MDA-MB-231 cell line a choice for anticancer activity testing of Taxanes.
A cell line remains a cell line and appart specific mutations you could search for a specific cell line, you can use many different cell lines.
The best strategy is to go to the public site of the US NCI (I am attaching here the link) and to look at the profile of the 60 cancer cell lines to a given compound, here taxol for example.
I just made the exercice for you and the file is here attached.
You will see for this chart that MDA-MB-231 presents a "quite standard" profile of "anti-tubulin sensitivity", while certain other cell lines are much more sensitive versus much more resistant.
I am also attaching here an article that will help you to understand the NCI graph in case of you are not familiar with this type of presentation.
You can also decide to choose cells with different sensitivity to anti-tubulin compounds (see Lefranc - Nunzo et al., here attached).
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