I cannot find the IC50 value of 5-FU against HT-144 cancer cells, as determined via cytotoxicity analysis. I shall be thankful if someone help me with relevant literature.
Hi Noor ul Ain ,
1. Researchers used different cell line to assess a single compound for its efficacy.
2. I hope you have been gone through the literature on it and could not find the required one.
3. I am attaching one publication not on HT-144 cell line.
4. But, you can go through this also if could not earlier, may be helpful for you.
5. If you are not able able find its known IC50 try evaluating and you will be with an IC50 on your cell line of your interest.
Thank you,
Good luck
Be sure to check out GDSC database. To my knowledge, it is one of the biggest (if not the biggest) database of cancer cell lines and anticancer drugs available.
There is a IC50 value reported for 5-F in HT-144. However you will have to dive into the references to have a good idea of how the value was estimated and if it fits your conditions. As a reference compared to other cell lines or treatments it is still quite useful.
This link should take you directly to where you could find the IC50 for 5-f in that cell line.
https://www.cancerrxgene.org/compound/5-Fluorouracil/179/by-tissue?tissue=PANCANCER&screening_set=GDSC1
Mauricio de la Rosa-Garza I highly appreciate your help. I could not find this information anywhere else. Thanks a lot!
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