I am planning to investigate the effects of agrochemicals on the function of kidneys using an animal model. Ideally I could use a primate model. But i am reluctant due to handling/ maintenance concerns. What animal model (rodent, rabbit, dog etc.,) would have the pharmacodynamics of ingested agrochemicals more similar to that of humans?
Best non-primate animal model to test the effects of agrochemicals as LD50 /LD90 of the agrochemicals for rat is expected for comparison of the toxicity .
I believe the concerns for using primates are more of an ethical nature. There is no required regulatory testing for pesticides on primates nowadays. The models that are used are (in decreasing order of use): rat, mouse, rabbit, dog.
All pesticides are tested in mammalian models, including an assessment of kidney toxicity, before they are allowed on the market, so if you are looking to place your research into context and have comparable data available, it would be best to use rat or mouse models.
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