In chemical-induced colitis-associated cancer mouse models, treatment of mice with azoxymethane (AOM; a mutagen and carcinogenic compound) and dextran sodium sulphate (DSS) in colon epithelial cells activates a number of signaling pathways during the development of tumors in the colon. These pathways include the p53-pathway.
Dear Professor
During one of my PhD experiences, an assignment about intestinal crypts modelling for colon canacer insight (I validated the biological model reduction_see Ext Abstract), I collected several sources to provide a thorough biological perspective (I was dealing with informaticians) to give an "actors list" for model building. One of this sources helped me to define the main frame, regardind crosstalk between WNT, BMP, Hedgehog and Notch, which pathways interact at different levels with P53 --> See attached paper
I hope it will be useful, for more info please contact me without hesitation.
Castaldi DF
p53 is a tumor suppressor gene and is responsible for apoptosis of tumor cells. In chemically induced AOM/DSS mouse model, mutation of p53 due to lipid per oxidation and NF-kappa B, drive the colonic inflammation to colon cancer.
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