What are most acceptable mouse models of Alzheimer's disease?

More Divaker Choubey's questions See All

What is known about the role of p53 pathway in the development of colorectal cancer (CRC) using mouse models?

In chemical-induced colitis-associated cancer mouse models, treatment of mice with azoxymethane (AOM; a mutagen and carcinogenic compound) and dextran sodium sulphate (DSS) in colon epithelial...

03 April 2016 5,357 4 View

What do we know about the role of inflammasomes in the development of inflammation-associated human cancers?

Studies in certain mouse models have indicated that activation of inflammasomes protects against the development of cancers. However, the role of inflammasomes remains unclear in the development...

01 February 2015 9,557 7 View

Does anyone know a commercial source of adenoviral expression vector to express the interferon-alpha?

We would like to over express the IFN-alpha gene in primary cells after adenoviral delivery.

08 September 2014 9,026 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

What analysis to choose with a large neste dataset and clearly skewed or kurtotic distributions?

Hello! I have a dataset of n=3000 nested within 8 countries with approximately 200 or 400 responses in each country. I originally planned to perform multilevel modelling with 4 dependent variables...

02 March 2021 6,865 1 View

How to plot the probability paper of Gumbel distribution using R programing?

In R-studio, there are many commands of Gumbel package. Arguments are also different. I`m asking about the alpha parameter of the Copula which must be greater than 1. If this is the one used to...

25 February 2021 5,229 3 View

How to handle studies which report perfect effect sizes in a meta-analysis using Pearson's r?

I'm in the process of updating a meta-analysis and in one of the new studies, effect sizes are reported as Tau-U. Two of the effect sizes are reported as Tau-U = 1.00. I am using Andy Field's...

24 February 2021 2,265 3 View

Alginate and silk fibroin hydrogels toxic to cells?

Hello, I asm currently working with alginate and silk fibroin hydrogels. I prepared a blend of alginate and aqueous silk fibroin (straight from dialysis) and resorted to ionic crosslinking to...

23 February 2021 8,249 2 View

Are there methods for automatically mapping floodplains, fans and terraces?

I want to map these river geoforms with as little subjectivity as possible. I have a high resolution DEM generated by drone data.

22 February 2021 7,800 3 View

Are there any databases for gene co-expression or expression pattern clustering?

I am currently working on gene clustering based on co-expression pattern in mouse brain. The problem is I do not have some solid way to test my result. Are there any suggestions for databases...

22 February 2021 4,374 3 View

How to visualise pathways from a phosphoproteomics dataset?

I am looking for something similar than Ingenuity Pathway Analysis (IPA) in which I can enter the proteins differentially phosphorylated and I can visualise the pathways these proteins are...

21 February 2021 8,923 4 View

How to read a flow cytometry graph detailing cell cycle?

Hello everyone, When determining cells in different stages of the cell cycle, cells are stain for Brdu and Propidium Iodide. I understand how PI can be used to discriminate between G1 and S/G2...

18 February 2021 3,920 3 View

Do I need to introduce HFD to ob/ob mice to obtain a T2DM model?

I am planning to work on T2 diabetic animals and check the efficacy of probiotics. My initial plan is to fed B6 animals with HFD for a while. But now, I have the chance to work on ob/ob mice. My...

18 February 2021 6,896 3 View

Mafalda Cacciottolo

In term of time and AD pathology, I would recommend the 3xTg, hardly used and you will find tons of papers about on pubmed. 5XFAD is good as well. I am using EFAD but most depend on what is your timeline and experimental design and whether or not you want to have a young vs old comparison.

Divaker Choubey

Thank you Mafalda.

Marcello D’Amelio

If you are interested to study early phase of AD, I would recommend Tg2576 mouse model. Tg2576 mouse model recapitulates AD-related synaptic dysfunction and loss without neuronal death.

Best

Marcello

Abdelaziz Ghanemi

Based on what I know, there is no animal model that has all the features of AD so the best would be to have many animal models and the "total" of these models would be close to the definition of AD features.