Studies in certain mouse models have indicated that activation of inflammasomes protects against the development of cancers. However, the role of inflammasomes remains unclear in the development of human cancers.
Contrary to the question, inflammation is classically recognized as a tumor-promoting factor. There have been several reports that demonstrate the contribution of inflammasomes to the tumor development. The activation of Nlrp3 in bone marrow-derived suppressor T cells by the administration of anti-cancer drugs leads to the development of secondly tumor via the paracrine secretion of IL-1beta. This notion is supported by the fact that Nlrp3-/- or IL-17-/- mice are resistant to the tumor growth.
Article Chemotherapy-triggered cathepsin B release in myeloid-derive...
Thank you Yoshida. The study is again in mice.
My question pertains to the role of inflammasomes in human cancers. It is likely that activation of inflammasomes that results in inflammation is associated with the development of certain human cancers. However, the actual evidences are still missing and studies involving mouse models are not very informative.
Even in the human hepatic tumor, inflammasomes associated with the change in the secondly bile acid is responsible for the malignant transformation of hepatic cells.
Probably Human gasteric cancer and Helicobacter pylori infection is a good axample for this question.
Thank you all for your responses. I believe that mutually complementary approaches are needed to examine the role of inflammasomes in myeloid and non myeloid human cells. The current studies involving certain mouse models are very difficult to interpret in light of human cancers.
For tumor induction, invasive infectious agents (viruses, bacteria, fungi and parasites) play a role and the hit and run mechanism is very likely, the infection defense certainly is a strong factor.
Sincerely
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