What are the mutation causing factors in BCR-ABL sequence, when the patient is treated for a long time with Gleevec?

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How many times can we use the same ?

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04 May 2016 1,060 3 View

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10 November 2015 288 1 View

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Tamjeed Saleh

There are quite a lot of mutations that show up on the Kinase domain upon Gleevec treatment. Most of the them are simple substitutions of 1 amino acid. The 13 aa substitution is from 1 report.

Alice Ceacareanu

Patient non-compliance with imatinib treatment and/or enrichment in a pre-existing resistant clone.

On a mechanistic side, see more about ERK1/2 involvement