Does any human cell line can replicate blood brain barrier microenvironment to be used for study of epilepsy and related pathologies?
Kindly confirm
See if it helps
https://www.researchgate.net/publication/282845471_Cell_Culture_Models_for_Studying_Epilepsy
https://www.frontiersin.org/articles/10.3389/fnins.2018.00590/full
Hello Asha Rao
You could use the iPSC-cortical neuron model. It could provide a valuable platform for simulating epilepsy. Please refer to the research article attached.
https://www.cell.com/stem-cell-reports/pdf/S2213-6711(21)00590-7.pdf
Best.
These two brain endothelial cell lines are said to be good models of the blood-brain barrier:
hCMEC/D3
https://web.expasy.org/cellosaurus/CVCL_U985
HBMEC/cibeta
https://web.expasy.org/cellosaurus/CVCL_4U95
Best regards
Amos Bairoch
Thank you so much Amos Bairoch Malcolm Nobre Vikrant Mehta
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