Hi Salma,

There are great papers from Prof. Tetsuya Terasaki's Lab on the protein analysis of tight junctions, transporters, receptors in different species such as this important paper: http://jpharmsci.org/article/S0022-3549(15)30936-9/fulltext

This paper is also important to show species differences in terms of permeability: http://dmd.aspetjournals.org/content/37/3/635.long#T3

In our review paper, we summarized these important papers in the field in Table-1: Article Stem Cell-Based Human Blood–Brain Barrier Models for Drug Di...

Or this paper can be useful to answer your question: Article Comparison of blood-brain barrier permeability in mice and r...

In general, BBB permeability to some drugs in rodents are more similar than the ones in other species. However, how the drug passes BBB (receptor-mediated, active transport, diffusion, etc.) is important to answer this question. So, it's better to focus on this question and search literature accordingly to see the differences among species. I hope this info is useful.

Hi Salma,

There are great papers from Prof. Tetsuya Terasaki's Lab on the protein analysis of tight junctions, transporters, receptors in different species such as this important paper: http://jpharmsci.org/article/S0022-3549(15)30936-9/fulltext

This paper is also important to show species differences in terms of permeability: http://dmd.aspetjournals.org/content/37/3/635.long#T3

In our review paper, we summarized these important papers in the field in Table-1: Article Stem Cell-Based Human Blood–Brain Barrier Models for Drug Di...

Or this paper can be useful to answer your question: Article Comparison of blood-brain barrier permeability in mice and r...

In general, BBB permeability to some drugs in rodents are more similar than the ones in other species. However, how the drug passes BBB (receptor-mediated, active transport, diffusion, etc.) is important to answer this question. So, it's better to focus on this question and search literature accordingly to see the differences among species. I hope this info is useful.

thanks dr Sezin for your useful information

Probably it does in rats too. Because the rules for BBB passage are quite general.The rules are: 1) the mol weight should not exceed 500.2)the more lipophylic the drug is the better it passes, but there is an optimum, when the lipophylicity passes this optimum, the passage is worse, probably because it sticks to the endothelial cell.3) it also means that the substance should not be ionized, because ions do not pass.4) the passage of gasses such as Oxygen or CO2 is free. See my book: Cerebral Pathophysiology by K.G. Go, Elsevier 1991.

thanks dr Gwan Go and Entedhar Sarhat for this useful information

Entedhar Sarha : Please stop plagiarizing other people's published work and presenting it as your own on this and other websites.

*Salma, I would not thank someone like Entedhar Sarha who just joined Researchgate and already has plagerized dozens of articles ! They are a discredit to all honest scientists.