If dominant negative mutations are well recognised in TP53, APC and ATM why have they not yet been reported in BRCA1 and BRCA2?

10 July 2021 0 891 Report

Germline mutations in a number of cancer predisposition genes have been reported to have a dominant negative effect reducing availability of protein from the wild type allele. As there are functional domains in both BRCA genes why have we not yet identified these in the BRCA1 and BRCA2 genes?

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