How to calculate the chemical potential of amorphous solids using sorption/desorption data?

Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.

01 February 2019 3,211 1 View

How to calculate the paired distribution functions of amorphous solid from PXRD DATA (eva file)?

Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?

11 December 2018 2,215 3 View

Can anyone would like to share some excellent literature about the calculation of solubility parameters of organic molecules including polymers?

The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.

11 December 2018 1,504 0 View

What are the factors that determine the stability of amorphous solids?

Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...

10 November 2018 7,799 0 View

What is the hydrogen bond acceptor strength of two hydrogen bond acceptor groups present in PVP k30 polymer?

PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...

09 October 2018 3,435 0 View

How to characterize the amorphous-amorphous phase separation ?

i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?

07 August 2018 7,127 0 View

How to characterize the miscibility of the two polymers in the solution state?

can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...

06 July 2018 5,497 0 View

How to characterize the adsorption of smaller particles on a larger one?

Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.

05 June 2018 9,191 3 View

How to calculate the theoretical amorphous "solubility" of an API?

i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.

05 June 2018 3,581 0 View

What differences might be there in the SSNMR spectra of crystalline and amorphous phases of an API?

How to characterize amorphous phases of pharmaceuticals with solid state NMR ?

04 May 2018 6,350 0 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Is there any teachers based in UK who would like to take part in my study?

24 February 2021 4,833 3 View

How can Gamma Ray API units be converted to CPS (counts per second)?

Oil and gas companies run gamma ray tool and take readings in API units while Gamma ray is also noted in cps, so how these units can be converted into each other?

24 February 2021 7,545 2 View

Do you kow of any database containing data on retention time, log P and polarizability for a large number of molecules?

Hi, I am a chemistry undergraduate doing my dissertation project on HPLC. In my project, I need to predict the HPLC retention time of 20 aromatic molecules, the calibration set. To do this I will...

24 February 2021 2,602 1 View

How to seperate PEG-4000 from aqueuse phase ?

Hello everyone , Please tell me if It possible to seperat POlyethelyn glycol -4000 from an aqueuse media by other ways rather heating . I have tried salting out by electrolyte solution to...

22 February 2021 7,285 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

How to analyse monosaccharide compositions from soluble fiber?

I have tried to hydrolyze the sample using 2 M TFA at 100C for 24, 48 h and 120C for 2 h. From these conditions, the HPLC results showed that peaks were not separated into monosaccharide. I found...

17 February 2021 5,230 1 View

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Hello. I ask for help - I need to get lithium tetraborate (soluble salt) from lithium carbonate and boric acid. In literature, everything seems to be simple - mix, ignite and - it's done. But it...

16 February 2021 9,523 2 View

Is There are any idea to achieve H NMR signals for swollen compound ??

the samples are not completely soluble - just swelled the solvents that's mean the sample may be partially soluble any suggestion, please

16 February 2021 8,801 3 View