How to characterize amorphous phases of pharmaceuticals with solid state NMR ?
Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.
01 February 2019 3,211 1 View
Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?
11 December 2018 2,215 3 View
The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.
11 December 2018 1,504 0 View
Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...
10 November 2018 7,799 0 View
PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...
09 October 2018 3,435 0 View
i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?
07 August 2018 7,127 0 View
I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?
06 July 2018 9,625 0 View
can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...
06 July 2018 5,497 0 View
Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.
05 June 2018 9,191 3 View
i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.
05 June 2018 3,581 0 View
Hello, I am working on the photocatalytic degradation of PEG 400. I would like to know if it's possible to determine the degree on polymerization based on NMR integration, or by the MW of the...
02 March 2021 6,186 3 View
I would like to research on MR images (0.5T and 3T). Can you please suggest some websites that I can download dataset including both 0.5T and 3T MR images? Thank you.
02 March 2021 7,735 3 View
I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...
01 March 2021 3,703 3 View
Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.
28 February 2021 7,883 3 View
Hi researchers, I am searching for some accurate way to do the circuit modeling of planar CPW-fed monopole antennas. I have gone through the literature where mostly circuit modeling is done using...
28 February 2021 7,016 1 View
hello. i am junior researcher. I received a comment from a reviewer that he could not find NMR data in my submitted paper. I had included the NMR graph with explanation and formula to calculate...
27 February 2021 734 4 View
Oil and gas companies run gamma ray tool and take readings in API units while Gamma ray is also noted in cps, so how these units can be converted into each other?
24 February 2021 7,545 2 View
I performed a Proton NMR of graphene powder prepared by electrochemical exfoliation technique. It shows some peaks. But I can't understand it.
21 February 2021 8,947 3 View
Hi, I have modelled a three-span arch bridge with soil fill over along with pedestals. The FE modelling is done in LUSAS with HX8M solid elements (i.e. 3D solid modelling). The non-linearity is...
20 February 2021 1,346 2 View
Hi Everyone, I am trying to develop an SPE method for the vaccine which contains Matrix-M (saponin Quillaja Saponaria ) which is in nano-particle form and size is around 40nm. These nanoparticles...
16 February 2021 1,389 2 View