How to calculate the chemical potential of amorphous solids using sorption/desorption data?

Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.

01 February 2019 3,211 1 View

How to calculate the paired distribution functions of amorphous solid from PXRD DATA (eva file)?

Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?

11 December 2018 2,215 3 View

What are the factors that determine the stability of amorphous solids?

Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...

10 November 2018 7,799 0 View

What is the hydrogen bond acceptor strength of two hydrogen bond acceptor groups present in PVP k30 polymer?

PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...

09 October 2018 3,435 0 View

How to characterize the amorphous-amorphous phase separation ?

i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?

07 August 2018 7,127 0 View

How would i know the required solubility of an API for the development of solid oral dosage form?

I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?

06 July 2018 9,625 0 View

How to characterize the miscibility of the two polymers in the solution state?

can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...

06 July 2018 5,497 0 View

How to characterize the adsorption of smaller particles on a larger one?

Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.

05 June 2018 9,191 3 View

How to calculate the theoretical amorphous "solubility" of an API?

i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.

05 June 2018 3,581 0 View

What differences might be there in the SSNMR spectra of crystalline and amorphous phases of an API?

How to characterize amorphous phases of pharmaceuticals with solid state NMR ?

04 May 2018 6,350 0 View

Chlorinated organic formation in odor control scrubbers using hypochlorite?

I'm involved in a study of odor control technologies for municipal wastewater treatment plant. One of the control options involves a chemical 2-stage (acid/alkaline) packed bed scrubber. The...

03 March 2021 3,661 2 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

Can polymer concentrations be calculated based on the number average molecular weight?

Hello, I spin-cast two different polymers onto wafers and measure their height as a function of initial concentration. For polymer A, I have the weight-average molecular weight (Mw) as well as...

28 February 2021 7,882 2 View

What is the density for pva electrospining?

I'm Juan Carlos, a high school student who is working with electropinning, I made an electropinning machine with a 21g needle and a 30kv high voltage source and the distance between my needle is...

28 February 2021 298 3 View

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I am trying to find how to know the density needed for a pva electrospinning in a 0.6mm neddle, the electrospinning will be from top to bottom and the problem I really have is the solution because...

25 February 2021 2,615 3 View

How can we theoretically calculate Elemental analysis(percentage) of atoms in covalent organic framework?

For example in one research article the Elemental analysis values of COF-TpPa-1 ( Triformylphloroglucinol (Tp) (63 mg, 0.3 mmol), Paraphenylenediamine (Pa-1) (48 mg, 0.45 mmol) are as follows...

24 February 2021 1,265 6 View

Do you kow of any database containing data on retention time, log P and polarizability for a large number of molecules?

Hi, I am a chemistry undergraduate doing my dissertation project on HPLC. In my project, I need to predict the HPLC retention time of 20 aromatic molecules, the calibration set. To do this I will...

24 February 2021 2,602 1 View

How to Control Whiteflies in coconut leaves?

24 February 2021 1,005 1 View