15 Questions 3 Answers 0 Followers
Questions related from Mahendra Singh
Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.
02 February 2019 3,257 1 View
Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?
12 December 2018 2,281 3 View
The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.
12 December 2018 1,549 0 View
Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...
11 November 2018 7,844 0 View
PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...
10 October 2018 3,471 0 View
i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?
08 August 2018 7,179 0 View
I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?
07 July 2018 9,673 0 View
can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...
07 July 2018 5,543 0 View
i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.
06 June 2018 3,636 0 View
Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.
06 June 2018 9,240 3 View
How to characterize amorphous phases of pharmaceuticals with solid state NMR ?
05 May 2018 6,425 0 View
We are trying to compare the characteristics of crystalline and amorphous phases of an API. In this context pair distribution function (PDF) is one of the characteristic feature of amorphous...
04 April 2018 4,205 3 View
solubility parameter (δ) provides a numerical estimate of the degree of interaction between materials, and can be a good indication of solubility, particularly for nonpolar materials such as many...
04 April 2018 4,628 2 View
Some times organic solvent is used in the spray drying process. how we can determine the residual solvent in spray-dried samples?
04 April 2018 6,964 3 View
how we can calculate the maximum possible solubility for an API?
03 March 2018 3,282 1 View
