PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N atom of pyrrole ring.
Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.
01 February 2019 3,211 1 View
Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?
11 December 2018 2,215 3 View
The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.
11 December 2018 1,504 0 View
Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...
10 November 2018 7,799 0 View
i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?
07 August 2018 7,127 0 View
I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?
06 July 2018 9,625 0 View
can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...
06 July 2018 5,497 0 View
Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.
05 June 2018 9,191 3 View
i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.
05 June 2018 3,581 0 View
How to characterize amorphous phases of pharmaceuticals with solid state NMR ?
04 May 2018 6,350 0 View
I'm a graduate student who works with an anaerobe, so I often work in an anaerobic chamber. I've been working on an assay that involves the steady-state of the quinone/ quinol pool. Anoxic...
03 March 2021 2,971 1 View
(This statement is from wikipedia, BTW). What is so special about metallic bond that is limiting high-P low-T state of a matter (as long as individual atoms exist, not white dwarf of neutron star...
02 March 2021 3,309 2 View
It is oftentimes said to be a distinctive metallographic trait that differentiates a fully austenitic and a fully felly ferritic steel without etching that might distinguish between two. Why...
02 March 2021 728 2 View
I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...
02 March 2021 9,945 3 View
I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...
01 March 2021 3,703 3 View
I have used the i-Tasser several times, however it has been unavailable for several days. I tried the swiss-model, but the output was not very pleasant due to the model used. Is there any other...
28 February 2021 4,521 3 View
Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?
28 February 2021 1,577 1 View
Hi everyone How to model Supercritical water gasification (SCWG) process in Homer software?
25 February 2021 4,075 1 View
I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...
24 February 2021 1,534 2 View
Hi, I am a chemistry undergraduate doing my dissertation project on HPLC. In my project, I need to predict the HPLC retention time of 20 aromatic molecules, the calibration set. To do this I will...
24 February 2021 2,602 1 View