i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.
Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.
01 February 2019 3,278 1 View
Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?
11 December 2018 2,308 3 View
The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.
11 December 2018 1,567 0 View
Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...
10 November 2018 7,869 0 View
PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...
09 October 2018 3,489 0 View
i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?
07 August 2018 7,198 0 View
I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?
06 July 2018 9,693 0 View
can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...
06 July 2018 5,563 0 View
Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.
05 June 2018 9,260 3 View
How to characterize amorphous phases of pharmaceuticals with solid state NMR ?
04 May 2018 6,452 0 View
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05 August 2024 4,407 0 View
Just bounced on me. Before statistically analysing significant difference, shouldn't we see if data fits normal distribution first? Is 3 replicates enough to testify the hypothesis of normal...
31 July 2024 8,141 13 View
Hello everyone, I am try to understand the differences interaction between insoluble and soluble polymers in water with metal ions and how theit charge density (of metal ions) affect the interaction.
29 July 2024 6,350 3 View
Dear all: I am modifying Bismuth Tungstate with Hematite (Fe2O3), so I would like to know about how much Iron(+3) can form a solid solution in a Bismuth Oxide matrix. Best wishes Marco
29 July 2024 2,163 1 View
PDE value for Tert-Butylamine
24 July 2024 1,166 0 View
I was performing estimation of Total Soluble Sugar content in bacterial cultures by Anthrone method. Out of 9 samples, only one sample showed positive reading while others had a negative reading...
22 July 2024 9,576 4 View
Hello, I have a somewhat weird question: has anyone had problems with campylobacter growing in the second half of the strip GLU through ERO? Have you managed to correct it? There is some...
19 July 2024 3,094 2 View
I have extracted essential oil from a medicinal plant and want to make several concentrations for some biological activities (Antidiabetic assay). How can i prepare the several concentrations to...
04 July 2024 8,100 4 View
AGN (Active Galactic Nuclei) are high energy galaxies powered by supermassive blackholes. The evolution of a galaxy is characterized by parameters such as luminosity and redshift. The redshift is...
25 June 2024 3,782 2 View
Hi Dear Researchers, Could anyone please provide me with some information about the HPLC column, specifically the “Purospher STAR RP-18 LiChroCART Cartridge”? I would like to know if it is...
25 June 2024 9,523 1 View