02 February 2019 1 3K Report

Crystalline and amorphous solids have different chemical potentials. May be this is one of the reasons of higher reactivity of amorphous solids.

More Mahendra Singh's questions See All
How to calculate the paired distribution functions of amorphous solid from PXRD DATA (eva file)?

Paired distribution function (PDF) is the characteristic of amorphous solids. How we can calculate this with the PXRD data?

11 December 2018 2,308 3 View

Can anyone would like to share some excellent literature about the calculation of solubility parameters of organic molecules including polymers?

The very first requirement of the mutual solubility of chemical compounds is that the solubility parameters of these chemical species should not differ too much.

11 December 2018 1,567 0 View

What are the factors that determine the stability of amorphous solids?

Amorphous solids are unstable. A number of environmental factors may induce their conversion to their crystalline counterpart. This vanish the solubility advantage of amorphous pharmaceutical...

10 November 2018 7,869 0 View

What is the hydrogen bond acceptor strength of two hydrogen bond acceptor groups present in PVP k30 polymer?

PVP is the frequently used polymer in the solubility improvement of poorly soluble drugs. Structure elucidation revealed that there are two hydrogen bond acceptors (amide carbonyl group and N...

09 October 2018 3,489 0 View

How to characterize the amorphous-amorphous phase separation ?

i would like to know that how we can characterize the amorphous-amorphous (amorphous drug and amorphous polymer) phase separation?

07 August 2018 7,198 0 View

How would i know the required solubility of an API for the development of solid oral dosage form?

I am trying to develop a solid oral dosage for an API. how i would know the optimum solubility for this API?

06 July 2018 9,693 0 View

How to characterize the miscibility of the two polymers in the solution state?

can someone let me know that how to characterize the miscibility of two polymers in the solution state? The miscibility of two polymers in solid state is characterized by the single Tg in DSC...

06 July 2018 5,563 0 View

How to characterize the adsorption of smaller particles on a larger one?

Can someone help me in the characterization of adsorbed smaller particles on bigger particles? i have used only one technique that is scanning electron microscopy to visualize the adsorbed particles.

05 June 2018 9,260 3 View

How to calculate the theoretical amorphous "solubility" of an API?

i am trying to develop a formulation in which API will remain in the amorphous form. I am facing problem with the calculation of theoretical amorphous solubility.

05 June 2018 3,663 0 View

What differences might be there in the SSNMR spectra of crystalline and amorphous phases of an API?

How to characterize amorphous phases of pharmaceuticals with solid state NMR ?

04 May 2018 6,452 0 View

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