Millions ask how vaccines of covid 19 be successful and safe, its here to explain generally how vaccine of pfizer work ,mRNA vaccines teach our cells how to make a protein that will trigger an immune response without using the live virus that causes COVID-19. Once triggered, our body then makes antibodies. These antibodies help us fight the infection if the real virus does enter our body in the future.
‘RNA’ stands for ribonucleic acid, which is a molecule that provides cells with instructions for making proteins. Messenger RNA (mRNA) vaccines contain the genetic instructions for making the SARS-CoV-2 spike protein. This protein is found on the surface of the virus that causes COVID-19.
When a person is given the vaccine, their cells will read the genetic instructions like a recipe and produce the spike protein. After the protein piece is made, the cell breaks down the instructions and gets rid of them.
The cell then displays the protein piece on its surface. Our immune system recognizes that the protein doesn’t belong there and begins building an immune response and making antibodies.
Now for other vaccines,How they work?
A the world find means to control covid 19 by vaccination ,new variants came to spread and make the world in fear and danger, to understand the conduct of these variants, es constantly change...
21 February 2021 3,080 6 View
Seniors in the world with diabetics and hypertension and heart diseases are millions ,and they are facing covid.therefore we should give them advices and precausions to face covid 19,this...
26 January 2021 8,349 4 View
Who is now working very hard with return of America to its active membershipnow WHO is concentrating on vaccinations,here are some activities, provides summary tables of COVID-19 vaccine...
20 January 2021 9,593 8 View
Millions in the world asking vwhat happened if taken vaccine of vcovid 19 ,and many want emphasis and proofs that this vaccine is safe, yes. The COVID-19 vaccines created by Pfizer and Moderna do...
02 January 2021 2,750 7 View
We hope to recover, and the economy improved by using vaccination .and vaccines is needed. The vaccine will protect you from getting ill and then ending up hospitalized. But it's possible that...
02 January 2021 4,194 4 View
2020is finished and was very hard for millions now how to welcome new year.now what is our wishes in new year e year 2020 has been an unpredictable ride through the pandemic, protests and many...
01 January 2021 1,200 5 View
Millions in the world seeking immunity against covid 19, we hope that when taken vaccine ,we activate our immunity and our memory cells will learn how to fight covid 19 if it comes to our...
23 December 2020 8,201 5 View
After one year we are now getting vaccines of covid 19but millions want to take it and others are afraid of any harm so how to convince millions to take it.According to FDA ,the comittee...
14 December 2020 852 4 View
As millions are getting depressed losing health and job and loniliness ,anew hope is begining to build up.really we need to this encouragement.we need all hygene ,distant physically to immune...
12 November 2020 159 4 View
I did sds page to determine the difference in protein expression between 3 types of vaccine , but i don't have scanner or densitometer available. . so i wonder if there is a software to analyze...
02 March 2021 6,270 3 View
I want to know which of the available Covid-19 Vaccines would elicit the best immunological response and why
02 March 2021 1,388 3 View
Dear respective researchers, I was asked by my institution to be vaccinated this week using the sinovac vaccine. However, from some of the information I got, this vaccine is not recommended for...
01 March 2021 7,781 6 View
I transfected my LNCaP-WT cells with 3 shRNA plus their NTC two weeks ago and split two puromycin selected cell plates on Friday last week(Feb 26). I checked for GFP in the cells, and they all...
28 February 2021 4,949 3 View
Hi, I'm looking for public datasets that have CT, X-ray information, or medical records for patients with Covid-19. Does anyone have suggestions?
28 February 2021 4,760 3 View
Are there any published or unpublished statistics or papers on the dropout rate (Dose1 to Dose-2) for Covid-19 vaccination in India, USA, UK, or any other country where vaccination has started at...
28 February 2021 4,237 1 View
hi everyone, I'm interested in the field of vaccine design specifically multi-epitope cancer vaccines , I want to know if there is a minimum and maximum number of epitopes we could use in a...
27 February 2021 3,882 3 View
Wether vaccine passport declared not to go out of home without it may help taking COVID-19 vaccine. Can't it break individual's right to protect the community? Your comments on perspectives...
27 February 2021 5,549 23 View
Or will we have to get vaccinated every year, as in the case of influenza?
27 February 2021 1,048 5 View
Please see the link below.
Well thanks for explaining the Pfizer, definitely other vaccination also will play the same role to protect from this deadly virus.
How to deliver *foreign mRNA* as vaccine into our body?
The important question is that how to deliver the 'foreign mRNA' as vaccine into our cells. Because mRNA is a fragile molecule and very easy to be degraded. So, we need a specific way to protect mRNA safely goes into our body. To deliver 'foreign mRNA (ex. COVID vaccine)', scientists have developed (take many years of trial and error) a *lipid nanoparticle* to wrap the foreign mRNA up (see attachment). The mRNA is protected inside the nanoparticle made out of lipid.
Diagram from Science: https://science.sciencemag.org/content/370/6520/1022
How does *Lipid nanoparticle* look like?
I mentioned the lipid nanoparticle above. But, how does lipid nanoparticle look like in reality? Here is one great Figure. Left, diagram. Right, lipid nanoparticle under
Diagram is from: https://www.americanpharmaceuticalreview.com/Featured-Articles/364236-Recent-Advances-in-Lipid-Nanoparticle-Mediated-mRNA-Therapy/