Millions ask how vaccines of covid 19 be successful and safe, its here to explain generally how vaccine of pfizer work ,mRNA vaccines teach our cells how to make a protein that will trigger an immune response without using the live virus that causes COVID-19. Once triggered, our body then makes antibodies. These antibodies help us fight the infection if the real virus does enter our body in the future.
‘RNA’ stands for ribonucleic acid, which is a molecule that provides cells with instructions for making proteins. Messenger RNA (mRNA) vaccines contain the genetic instructions for making the SARS-CoV-2 spike protein. This protein is found on the surface of the virus that causes COVID-19.
When a person is given the vaccine, their cells will read the genetic instructions like a recipe and produce the spike protein. After the protein piece is made, the cell breaks down the instructions and gets rid of them.
The cell then displays the protein piece on its surface. Our immune system recognizes that the protein doesn’t belong there and begins building an immune response and making antibodies.
Now for other vaccines,How they work?
Tareq Alasadi
Please see the link below.
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/how-they-work.html
Thanks!
Well thanks for explaining the Pfizer, definitely other vaccination also will play the same role to protect from this deadly virus.
Part I.
How to deliver *foreign mRNA* as vaccine into our body?
The important question is that how to deliver the 'foreign mRNA' as vaccine into our cells. Because mRNA is a fragile molecule and very easy to be degraded. So, we need a specific way to protect mRNA safely goes into our body. To deliver 'foreign mRNA (ex. COVID vaccine)', scientists have developed (take many years of trial and error) a *lipid nanoparticle* to wrap the foreign mRNA up (see attachment). The mRNA is protected inside the nanoparticle made out of lipid.
Diagram from Science: https://science.sciencemag.org/content/370/6520/1022
Part II.
How does *Lipid nanoparticle* look like?
I mentioned the lipid nanoparticle above. But, how does lipid nanoparticle look like in reality? Here is one great Figure. Left, diagram. Right, lipid nanoparticle under
microscope.
Diagram is from: https://www.americanpharmaceuticalreview.com/Featured-Articles/364236-Recent-Advances-in-Lipid-Nanoparticle-Mediated-mRNA-Therapy/
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