How to identify the targets of caspase ?

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Emmanuel Datan

Hi Kovuru,

You are correct about the paradox between the differentiation and death functions of caspases. There is an expert of this duality J.M. Hardwick at Johns Hopkins who wrote a chapter in a recent book on 20th anniversary of the international cell death society/ICDS (https://www.researchgate.net/publication/301359529_Cell_death_and_virus_infection_-_a_short_review, THIS LINK IS ONLY FOR ONE CHAPTER, Dr. Hardwick's article is in the table of contents and is not open access. Book is in amazon). There is also this insightful research article (not review) that shows how important caspases are in mammalian development (http://www.ncbi.nlm.nih.gov/pubmed/15744667).

Regarding your other question, you can visit this database on caspase substrates (http://caspdb.sanfordburnham.org/). Enjoy!

-ED

Chapter Cell death and virus infection – a short review

Narasaiah Kovuru

Thanks mam