upon TLR2 stimulation we found both IL1 beta and IL10 were induced why both were induced.
Because TLR2 lead to activation of innate immunity cells especially macrophage. Macrophage when activated secrete the inflammatory (pro and anti) Cytokines.
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200193
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TLR2 activate signaling cascades in T cells that activate IL10 gene and production of IL-10.
Article T cell-intrinsic TLR2 stimulation promotes IL-10 expression ...
TLRs are members of the IL-1R superfamily. In cytoplasmic domain, TLRs show significant homology to the IL-1 receptor type I and IL-18 receptor. This domain contains a conserved region called the Toll/IL-1R (TIR). Recognition of PAMPs by TLRs recruits MyD88, IRAK kinase, and TRAF6 [1]. These adaptor molecules mediate the activation of the JNK, p38, ERK 1/2, NF-κB, and phosphoinositide 3-kinase signaling pathways leading to activation of inflammatory target genes .
Article TLR2 Expression in Relation to IL-6 and IL-1β and their Natu...
While pro-inflammatory cytokines are destined to promote inflammation and anti inflammatory cytokines are inhibiting inflammation. but why both are secreted simultaneously what would be the out come ? whether they promote inflammation or inhibit inflammation ?
Article Toll-Like Receptors in Skin Infections and Inflammatory Diseases
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