There is a reason compounds such as tocopherol are classified as "hydrophobic" - as in they hate water! ;)
You could use solvents with lower dielectric constant that water to improve the solubility. Also, there are methods to emulsify or stabilize them or use certain polymeric compounds for assisting with the process such that a small amount of uniform suspension can be added to a large quantity of aqueous solution. If the concentration needed in the final solution is very low and there are other components, for example carrier proteins, such as serum albumin, you may achieve your goal.
I'm in the progress to induce melanoma on mice C57BL/6J by inoculating 1 million SKMEL28 (murine melanoma skin cancer) at the mice flank. But the melanoma is not developed until 30 days. Anyone has successfully experience and can share with me?
So sorry, I want to ask new question but wrongly send to previous forum. We already successfully dissolve the tocopherol in water with aid of tween 20. Thanks with the feedback.
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