I am wondering what is the % or number of Aa different to consider a protein as a new type or new variant?. I am working with new proteins (Kazal-type protease inhibitors). If you can suggest a reference would be great!
I'm not aware about any specific % or number of AA different that might be a definition for a new protein. I would suggest to consider any protein as a new protein if the revealed structural differences lead to a new function of the protein (excluding any post-translational modifications). In your case, if your protein had a different protein inhibitor specificity (or different binding sites, or different kinetics of binding) you might consider this protein as a new protein.
An example you might find useful is the classification of beta-lactamases, where any amino acid difference is considered a separate variant.
http://www.lahey.org/studies/
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