How entecavir works in hepatitis B?

29 October 2017 1 8K Report

As we know, entecavir is a DNA analogue that can inhibit HBV reverse transcription, by integrating itself into HBV genome during viral replication and blocking the cccDNA formation due to lack of hydroxyl group.

But I don't understand how it integrates into the HBV genome, is it through complementary machinery or just integrating into the viral genome randomly?

Luis Rodrigo

Entecavir is a guanosine analogue nucleoside with activity on HBV polymerase, it is effectively phosphorylated to the active form triphosphate (TP), which has a cellular half-life of 15 hours. When competing with the natural substrate deoxyguanosine-TP, entecavir-TP functionally inhibits the activities of the viral polymerase (priming, reverse transcription of RNA and synthesis of the complementary strand of DNA).

My best regards

Luis Rodrigo

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