How do you think about "DNA toxicity"?

12 December 2014 1 2K Report

I mean the toxicity is based on DNA sequence or its structure per se not the transcription or expression products from the DNA.

Marc-David Ruepp

The only example I know of are plasmids for SF3b1:

http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08387.x/full

There it seemed as the sequence of mouse SF3B1 was toxic and then Yokoi and colleagues made a mouse/Xenopus hybrid which could then be successfully cloned.

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