How do the immune changes of intestinal lamina propria and mesenteric lymph nodes affect the immune changes of spleen? Can intestinal lymphocytes migrate to the spleen?
Hi Lisa Jen, the immune changes occurring in the intestinal lamina propria and mesenteric lymph nodes can indeed affect the immune system in the spleen. The intestinal lamina propria and mesenteric lymph nodes are vital components of the gut-associated lymphoid tissue (GALT), which plays a crucial role in immune surveillance and response in the gastrointestinal tract.
The immune cells in the intestinal lamina propria and mesenteric lymph nodes are exposed to various antigens derived from the gut, such as pathogens and dietary particles. This exposure leads to the activation and differentiation of immune cells in these locations, including T cells, B cells, and antigen-presenting cells.
Following activation, some immune cells can migrate from the intestinal lamina propria and mesenteric lymph nodes to other parts of the body, including the spleen. This migration is facilitated by the circulation of lymphocytes through the lymphatic system and blood vessels. Once in the spleen, these migrated lymphocytes can interact with resident immune cells, influencing the overall immune response. Therefore, the immune changes occurring in the intestinal lamina propria and mesenteric lymph nodes can indirectly impact the immune changes in the spleen through the migration of activated lymphocytes
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