Very interesting observation. Could you please indicate the incidence rate and possible other factors (genetic and environmental)? Your responses would allow me to respond appropriately with respect to possible contributing factors.

Have you considered early onset active (and possibly passive) smoking as a factor that has increased in recent years among this young female population presenting with breast cancer? You might compare epidemiological smoking data of various years and correlate the two phenomena.

Thanks for the answers.

In Algeria, the smoking prevalance among females is rare. Thus smoking can't be considered as risk factor. However, in recent years there is “Westernization” of lifestyle (age of mariage: 32 yrs, lower parity, reduced breast-feeding, obesity, stress.

For detailed rates please read our article available for free on www.excli.de/vol13/Benarba_23062014_proof.pdf.

Many thanks.

Dear Bachir,

Have you checked and considered other risk factors such as: familial breast cancer,  genetic mutations in the BRCA1 & BRCA2 genes ( the inherited genes accounted for 20-25% of early age BC), radiation, exogenous hormones (P Pills), diet, obese and lack of physical activity. Additionally, reproductive events such as early menarcheand late age at first pregnancy ( after 30) could be also implicated as risk factors for BC.

Regards

Dear Bachir,

Since it seems there are no drug consumption (alcohol, tobacco) and no environment pollution, we must think about ethnicity-related factors. There are several hormone factors that have quite variable polymorphisms.

Kind regards,

FRPL

Dear Faustino R Perez-Lopez

Thanks for your answer

Bachir

Dear Nadia

I agree with you, westernization of algerian women lifestyle with less physical activity, diet, obesity and late age at 1st pregnancy but also lack of breastbreeding are factors that may contribue at this high incidence.

Thanks

Bachir

...think allways in lifestile , genetitcs and enviroment factors, all together., like the japaneses that get  colon cancer as they move to the US.!!! B est regards

I agree with responses above. I would like to add that in considering factors that may be contributing to an earlier development of breast cancer in Algerian women, one needs to consider the following factors: genetic factors, environmental factors (exposures to certain chemicals), and life style (including diet and lack of exercise). A genetic predisposition to development of certain cancers (including the breast cancer) remains a major contributor. Other factors that contribute to localized and systemic inflammation potentiate the development of cancers at an earlier age.

Thanks for your answers