There is a Co(III) mustard based prodrug which reduced in hypoxia environment and toxic to the cancer cells. if this complex reduced in cancer cell environment then why not other Co(III) complexes reduced to co(II)? if so what is criteria ? which type of coordinating ligand will facilitate the dissociation of inert Co(III) to labile Co(II)?
what are all the simple method to determine the stability cobalt(III) in biological environment? kindly give some relevant article.
May be i might not have completely understood your question i would like to answer half portion of your question regarding ligand field that can allow reduction of Co (III) to Co(II) Cobalt(III) low spin t2g6 which is inert however high spin Co(III) with t2g4 eg2 configuration is not inert i suppose ligands which can build up high spin complexes with Co(III) should allow reduction of Co(III) to Co(II) moreover Co(III) is a hard metal ion while Co(II) is borderline hence ligands with softer donor site should allow reduction of Co(III) to Co(II).
Hope it half answers the question.
I might be mistaken, but I think one is EPR silent, and the other is not.
Using a spin labeled Vit. B12 probe, the nitroxide bound to Co+3 is visible by ESR while the lines REVERSIBLE disappear with the +2 form. If this is further oxidized to +1, the nitroxide lines irreversibly disappear.
My inorganic book which grabbed from Progress in Inorganic Chemistry Vol 18.
I suspect there is a more modern method using some sort of Atomic Spectroscopy
May be i might not have completely understood your question i would like to answer half portion of your question regarding ligand field that can allow reduction of Co (III) to Co(II) Cobalt(III) low spin t2g6 which is inert however high spin Co(III) with t2g4 eg2 configuration is not inert i suppose ligands which can build up high spin complexes with Co(III) should allow reduction of Co(III) to Co(II) moreover Co(III) is a hard metal ion while Co(II) is borderline hence ligands with softer donor site should allow reduction of Co(III) to Co(II).
Hope it half answers the question.
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