Y.Manoj Kumar

11 Questions 13 Answers 0 Followers

Questions related from Y.Manoj Kumar

Why the binding affinity of photosensitizer with DNA has been studied ?

In general DNA targeted chemotherapeutic drug, interact with DNA and inhibit the DNA function finally cause the cell death (both normal and cancer cell). To understand the DNA binding ability of...

05 May 2018 8,796 1 View

Current intensity decreased due to DNA binding at the cathodic peak, but not in the anodic one. Why?

One of the reviewer asked me this question. The CV spectra show that for both the complexes, current intensity decreased due to DNA binding at the cathodic peak, but not in the anodic one....

03 March 2017 708 11 View

Why there were two absorption peaks at 252 and 277 nm of complex 1 and one peak at 269 nm for complex 2. ?

Complex 1 is [Cu(ip)2H2O](ClO4)2 Complex 2 is [Cu(dppz)2H2O](ClO4)2 Based on absorption spectral techniques i have studied binding ability of these complexes with DNA. A reviewer has raised a...

03 March 2017 4,391 3 View

Could any one help me to syntheis 5-(Aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide (CB1954)?

i am unable to get the procedure for synthesis 5-(Aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide (CB1954)? could any one help me to get related article ?

10 October 2016 6,840 2 View

Can we prepared iron oxide nano particle/ any nano particle in acidic condition (pH around 4 ) ?

In general, nano particle are prepared in basic condition. could any one suggest the procedure for preparation in acidic condition.

02 February 2016 5,454 7 View

What are the presubmission inquiry journals in ACS and RSC?

i am working on DNA binding and metal complexes .To publish my paper i would like to know the pre-submission inquire journals in RSC and ACS. kindly let me know the details.

06 June 2015 5,756 1 View

Is the MCF-7 cancer cell line a non-metastatic cancer cell line?

i want to compare anticancer activity of my metal complexes with the metastatic non metastatic cancer cell lines . some of them told that choose MCF-7 and MDA-MB-435 there are non-metastatic and...

06 June 2015 2,557 7 View

How can I determine the stability of Co(III) complex and also not reduce it to labile Co(II) in reductant ?

There is a Co(III) mustard based prodrug which reduced in hypoxia environment and toxic to the cancer cells. if this complex reduced in cancer cell environment then why not other Co(III)...

06 June 2015 7,759 4 View

How can I differentiate five coordination and six cooordination Co(III))metal complexes using UV Visible spectroscopy ?

I have synthesized some Cobalt(III) form the oxidation of cobalt (II) in this case when i take 1 mol ligand & one mole cobalt (II) compound containing tetradentate ligand the ligand ...

04 April 2015 6,186 7 View

Does the DMSO solvent influence the tyrosine intensity in Bovine serum albumin?

My metal complex neither soluble in water nor Buffer. it soluble in methanol,, CHCl3 ... but for the biological convenient i dissolved in DMSO solvent and dilution with PBS Buffer. During the...

02 February 2015 365 5 View

Is all coblat(III) metal complex reduced to Co(II) in cancer cell?

In normal buffer medium the Co(III) reduced to Co(II) in the presence of some reductant like Iron. Then eject the ligand which coordinate to the cobalt.since cancer cells have more reducing...

01 January 2015 8,752 2 View