Hi Anuradha Arya

First I would like to know that by saying in-silico approaches, did u mean target prediction tools or Drug-miRNA binding search tool???

If its target prediction tools then number of tools available in public domain such as miRDB, miRTAR, MirSYSyem, targetScan etc.

or if you are looking for Drug-miRNA binding then try Pharmaco-MiR tool.

I may not know about very specific miRNA and polyphenol interaction specific tool but Pharmaco-miR can work for you. this tool has enough information about drug- miRNA interaction, so any drug which resembles the polyphenol structure could give some idea of miRNA-polyphenol interaction idea.

Regards

Saurabh

Hello

As far as I know there is now accurate method to do it for you now.

Hi Anuradha Arya ,

Another option for you can be molecular docking approach by generating 3D structure of you miRNA and polyphenol and then performing molecular docking, it may provide you structural insights.

Hope this helps.

Best Wishes

Pankaj