I want to try using Plerixafor (AMD3100), an antagonist for CXCL12-CXCR4 binding in vitro. Could someone help me with the solvent that has to be used to dissolve and the shelf life post dilution?
We use DMSO as the solvent to the desired concentration. We then aliquot drug into vials containing enough AMD3100 for each experiment and freeze at 180oC. After thawing and use We discard any remaining drug. In our hand we have used the stored AMD3100 for up to 6 months without any observable change in activity.