Charan Thej

5 Questions 61 Answers 0 Followers

Questions related from Charan Thej

Has anyone used Plerixafor (AMD3100) in vitro?

I want to try using Plerixafor (AMD3100), an antagonist for CXCL12-CXCR4 binding in vitro. Could someone help me with the solvent that has to be used to dissolve and the shelf life post dilution?

21 October 2015 7,537 3 View

Where can i get a hepatic stellate cell line?

Does anybody know where I can get a human hepatic stellate cell line?Maybe LX-1 or LX-2? Who are the vendors for these cells?

12 November 2013 9,924 7 View

How does the Hepatic Stellate Cell activation occur in liver fibrosis/cirrhosis?

Does the activation of the HSCs occur by infiltrating macrophages or is it due to an upregulation of an activator like TGF beta? On what signal do the macrophages migrate into the liver?...

04 September 2013 9,482 7 View

Stem cell therapy for cartilage defects?

What could be the mechanism by which mesenchymal stem cells would be involved in cartilage defects like osteoarthritis?Is it a percentage engraftment and forming cartilage?Or is it by a 'hit and...

25 June 2013 4,999 4 View

Which of these are important in antifibrotic effects of the lung or liver: matrix metalloproteases or growth factors like HGF?

There could be two or three different pathways of HGF signalling: one to promote angiogenesis/survival and the other to have an antifibrotic effect (Ras-Raf-MEK-1-MAPK). In a scenario where...

27 May 2013 9,313 5 View