We make polysaccharide Nanoparticles, which are efficiently transported into the cancerous cells even against concentration gradient. What shell we put inside to kill cancer and spare normal cells? Nanoparticles sometimes get stuck in endosomes, how to force them out to cytoplasm?

Nanoparticles Diameter: 20-100 nm, depending on technology; composition: polysaccharide. Room temperature synthesis in water so we can encapsulate proteins, drug is covalently bound and released in endosomes. What type of drug shell we choose, we can use multiple drugs with synergetic effect, we can encapsulate proteins, RNA, various drugs that are normaly unable to pass cell membrane. Nanoparticles can be easily equipped in homing molecules – antibodies, what type of antibody shell we try.