8 Questions 50 Answers 0 Followers
Questions related from Tomasz Ciach
We have a good delivery system which passes cell membrane, we want to generate Reactive Oxygen or free radicals inside cytozol, how to do that? It can be either a single substance or a...
12 April 2016 5,885 8 View
Which properties of nanoparticles are responsible for transportation across BBB? Hydrophobicity, size, protein ligands, surface chemistry? How to modify NP surface to promote brain accumulation?
16 February 2015 9,899 15 View
At which pH imine formation reaction between water soluble aldehydes and primary amines is the highest? Can protonated amines take part in the reaction?
15 February 2015 3,825 18 View
.
30 August 2014 2,131 11 View
Most of artificial nanoparticles gets into the cell interior in endosomes. If they can’t be digested by the cell, they stay inside late endosome / lysosom vesicle. How long they can stay inside...
11 November 2013 3,435 2 View
Tumors in animal models, mostly mice, are usually very “young” and immature. We inject cancerous cells in matrigell and start administering nanoparticles within the next few days or a week. In the...
14 October 2013 2,981 3 View
We make polysaccharide nanoparticles for cancer treatment, they are efficiently transported into the cancerous cells even against concentration gradient, but they get stuck in endosomes /...
29 July 2013 4,839 8 View
We make polysaccharide Nanoparticles, which are efficiently transported into the cancerous cells even against concentration gradient. What shell we put inside to kill cancer and spare normal...
25 July 2013 4,117 0 View
