for mouse models of multiple sclerosis see

Docagne et al. Mol Cell Neurosci 34, 2007, 551-561

and

Baudron et al. Brain Behav Immunol 119, 2024, 381-393

Thank you Dear Dr. Duval,

I also aimed to create the EAE model, the second article will be very useful, thank you very much. Monsieur Duval je vous remercies beaucoups pour ces articles. Parce que Je n'ai pas pu trouver de méthode détaillée dans les articles que j'ai recherchés pour créer un modèle de souris EAE pour MS.

There are well established MS models: EAE, THeiler's virus, and others in various species.

Thank you Mr. Samuel. I also want to study Mulliple Sclerosis in EAE model in C57BI6 mice. I actually wanted to learn how to create EAE model by starting such a discussion on this platform. I wonder if it is possible to create this model other than knockout mice?

Yes, there are susceptible strains. They have to get knockouts and the like onto these backgrounds. You have to look up which are the susceptible strains to different techniques. The oldest technique is immunization with antigen and complete Freunds adjuvant. There are many techniques to induce disease. Copy someone elses which works with your chosen strain.

Tank you Dear Dr. Samuel, I will do research to create a model in different ways.