Dear all,

this question concerns a case study where 4 beagle dogs were administered a drug vehicle (PVP-K17, no active compound in formulation) through intramuscular (IM) administration; how likely is it for anaphylactoid reactions to be triggered by intramuscular injection of certain formulations?

All dogs showed symptoms resembling an anaphylactoid (non-IgE-dependent hypersensitivity) reaction (generalized erythema/skin redness, general pruritus with head shaking and rubbing, pawing the ground) and 1 animal showed what could best be described as sluggishness/decreased motoric coordination.

Symptoms manifested themselves 15-20 mins post administration and disappeared again approximately 1h post administration.

All animals were naïve in regard to PVP-K17 (no prior administrations) so there was no sensitization towards this vehicle/excipient (no anaphylaxis).

Any ideas/suggestions or insights would be very much appreciated, thank you in advance!