Yes, in immunology, CD12 (Cluster of Differentiation 12) is a designation for a protein that is expressed on the surface of certain cells in the immune system. However, as of my latest knowledge update in 2023, CD12 is not a well-characterized or widely recognized marker compared to other CD markers such as CD4, CD8, CD19, etc. The CD (Cluster of Differentiation) system is used to identify and classify surface molecules present on leukocytes (white blood cells) and other cells pertinent to the immune system.
Don't quote me on this but the numbering system for CD markers is extensive and covers a wide range of molecules, but "CD12" is not recognized in the current, widely accepted list of CD markers. This list is maintained by the Human Cell Differentiation Molecules (HCDM) organization and is continuously updated as new molecules are identified and characterized.
The List: https://www.hcdm.org/index.php/molecule-information
If you are encountering "CD12" in a specific context, it could be a typo, a less common or obsolete term, or possibly a designation used in a particular niche or unpublished research. Always refer to updated immunology resources or databases for the most accurate information on CD markers.
Hello Noble
The D12 are present on dendritic cell, macrophage, LB, LT, and plaquettes.
You can have more information here:
Scientist articles on the CD12 :
Functions of the CD12:
- "The Role of CD12 in Platelet Aggregation" by Ruggeri (2002) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224356/
- "CD12: An Antigen with Versatile Functions in Immunity" by Subramanian et al. (2012) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333615/
- "CD12: A Multifaceted Molecule in Innate and Adaptive Immunity" by Aliberti et al. (2014) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052397/
Therapeutics applied CD12:
- "CD12 as a Therapeutic Target for Thromboembolic Diseases" by Jackson and Nur (2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314228/
- "Targeting CD12 for Cancer Therapy" by Liu and Zhang (2016) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869362/
- "CD12 Blockade as a Novel Therapeutic Approach for Autoimmune Diseases" by Lan et al. (2017) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486091/
I think it's a new area of research which is yet to be fully established or confirmed. The claim is that CD12 is known to encode the CD12 antigen which are also involved in the regulation of immune responses. It is expressed on the surface of various immune cells, including NK and the T cells and also play a role in cell signaling and cytokine production. It is actually not part of well established CD markers.
Yes, there is something called CD12 in immunology.
While the function of CD12 is not fully established, some research suggests it might be expressed on the surface of certain immune cells and play a role in cell signaling and cytokine production.
More research is needed to fully understand the role of CD12 in the immune system.
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