Carcinoembryonic Antigen (CEA) gene family contains 33 genes/pseudogenes clustered within a region of 1.5 Mb on chromosome 19q13.2. Apart from being a reliable tumor biomarker for colorectal cancer (CRC), few members of the CEA family act as adhesion molecules and others as facilitators of the inflammatory response. Are there any studies linking the expression of CEA on cancer stem cells or circulating tumor cells with the enhancement of liver metastasis from CRCs? Are there any miRNAs or circular RNAs which might influence the turnover of CEA gene expression? Any new drugs in the pipeline against CEA?
Hi Kulvinder
The only paper I'm aware of discussing CEA and stem cells is the one from Olga:
Comparative analysis of colorectal carcinoma cell lines that differ in metastatic potential
A. P. Davydov-Sinitsyn · O. V. Bajenova · M. A. Liskovykh · [...] · E. N. Tolkunova
[Hide abstract]ABSTRACT: The present work is an attempt to compare cancer cells of the same origin but differing in the expression of CEA protein, a clinical marker of metastatic carcinomas. CEA, presumably, is one of the key factors in metastatic activity. We investigated the morphology of cell colonies in vitro, the expression pattern of epithelial markers, and the ability of these cells to form tumors and metastases in vivo. Their stem component was evaluated with a suicidal genetic construct sensitive to Oct4, an embryonic stem cell marker.
Article · Sep 2013 · Cell and Tissue Biology
regarding circulating cancer cells, there has been a lot of work done on identifying them by using PCR for CEA but as far as I know no one has looked for stem cells specifically. Again with liver mets lots of work with CEA as you know but nothing I'm aware of linking CEA to a stem cell population.
Peter
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