Kulvinder Singh Saini

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Questions related from Kulvinder Singh Saini

Can we rely on specific gene expression signatures from cancer stem cells and metastatic stem cells for predicting clinical outcomes in patients?

A recent report in Nature (Dec. 15, 2016) has identified 17 unique gene expression signatures for AML in leukemic stem cells, which could be useful in predicting “targeted therapies” and has the...

12 December 2016 7,671 2 View

CEA role in liver metastasis from colorectal cancer is well known. Any studies on CEA levels in cancer stem cells or circulating tumor cells & mets?

Carcinoembryonic Antigen (CEA) gene family contains 33 genes/pseudogenes clustered within a region of 1.5 Mb on chromosome 19q13.2. Apart from being a reliable tumor biomarker for colorectal...

08 August 2016 8,735 1 View

What are pros and cons of isolating cancer stem cells (CSCs) from established cell lines vs. primary tumors, for targeting CSCs with new drugs?

There are a number of reports for and against isolating CSCs from established cancer cell lines. One of the best work from Prof. Max Wicha lab, where they isolated CSCs from 33 breast cancer cell...

04 April 2016 6,803 4 View

Apart from ob/ob and Leptin mice, which other rodent models of obesity are employed for proof-of-concept studies of small molecule compound(s)?

We would like to evaluate small molecule compound(s), where exact mechanism-of-action is not clear at the moment. We are conducting in vitro studies right now and would like to extend these...

03 March 2015 6,041 3 View

Apart from Verastem, how many private/public biotech/pharma companies are working on targeting therapeutics against cancer stem cells?

List of public and private companies working on cancer stem cells? Any chance to see specific gene target (s), they work on? Where are their products in the drug discovery R&D pipeline? Are...

10 October 2014 7,784 3 View