In essence, you are describing the structure of a particle in a so-called nanoemulsion, comprised of an oily core with a monolayer at its surface. The monolayer can have different compositions (as can the core), but you will always need an energy input to form the particle. (The final particle size and the minimum amount of energy  required to reach the size depend on the oil and coating monolayer properties.) Cave: You should not identify a microemulsion (which is thermodynamically stable and forms on its own, subject to choosing the right blend) with a nanoemulsion (which is only metastable, i.e., typically kinetically trapped, but also has composition dependent properties. You can form the latter from some blends close to the blends that will produce the former.

As you seem to be interested primarily in phospholipid covered globular particles, you might wish to start with the information published by M. Kahlweit, G. Busse, and B. Faulhaber ( Langmuir 1995,11, 1576-1583 and Langmuir 1997, 13, 5249 - 5251) to identify the compositions suitable for your own purposes. You might also wish to take a look at  the figure 9 in Journal of Controlled Release 2012, 160, 135–146 for an illustration of the related generic phase diagramme. Using the latter for orientation, you should explore compositions near but not within a lamellar phase region (in which you can, under certain circumstances, prepare bilayer vesicles). A composition not too different from the compositions that yield bilayer vesicles after the corresponding lamellar phase fragmentation should provide you with the desired globular structures. Bear in mind, however, that your particles will have a finite surface tension (the further away you will be from a microemulsion the higher will be the tension) and therefore will ultimaltely coalesce. Charging up their surface will slow down the coalescence rate (dependent on particle surface charge density, charge screening by the background electrolyte (proportional to the square root of (1:1) electrolyte concentration), and particles density (determining interparticle separation and thus probability of aggregation).

Thank You Dr. Cevc, for your suggestions , I shall read the recommended papers, and then if i have certain problem I shall let you know. Thank You so much

Dear Dr. Cevc, I am interseted in making artificial rubber particle which simulates natural rubber particle. As the rubber particle from the latex are monolayerd phospholipids( i.e. phospholipids composed of fatty acids with two hydrocarbon tail But formation of monolayer micelle like structure in vitro is not possible with the two hydocarbon tails in the phospholipid . So, I have some idea, could  you please suggest whether the idea is feasible or not . 

Phospholipids usually have two hydrocarbon chains, so that the size of the phospholipid head is approximately the size of the two hydrocarbon chains together. This allows phospholipids to form a bilayer. If the phospholipids only had one hydrocarbon chain however, the head would be bigger than the single tail and its shape would be like a cone. Thus, the heads would form a circle around the hydrophobic tails and form a micelle rather than a bilayer . So, once we know the compostion of the lipids present in the rubber particle, we can take the pure phospholipids which are most dominant in the given ratio as seen in the rubber particle lipid composition. As we know phospholipase A2 (PLA2) are enzymes that relesase fatty acids from the second carbon group of glycerol. Thus the lipid when treated with PLA2 will lead to formation of phospholipid with only one hydrocarbon chain . The lysophospholipid formed after enzyme treatment could be separated from the phospholipid using two dimensional chromatography or HPLC. The lysophospholipid thus obtained should be mixed with water and be sonicted to form the micelle like structure. The surface structure of the micelle thus formed could be confirmed using SEM

Looking forward for your suggestions

Thanking You

sandeep