What is exact mechanism of metformin for sensitizing the insulin receptors and decreasing the serum glucagon levels?

Metformin a well known agent having multiple uses including the diabetes as a major use various effects has been mentioned in various books but the scientific justification is lacking can any body...

07 August 2018 1,492 6 View

Is there Any known association between family history and acquired aplastic anemia ?

Acquired aplastic anemia is of known itiology like drugs, toxins and radiation therapy but is there any relationship found like positive family history may also result in AAA ?

05 June 2018 5,187 3 View

What is the validity of a research question and who will decide it ?

It has been observed that research questions of low standard are being promoted by some so called researchers . Such questions have nothing to do with the scientific research. What is in your...

04 May 2018 3,630 5 View

What are the advantages and disadvantages of integrated module system of teaching for undergraduate medical students ?

Integrated module system of teaching is being adopted by many universities in the world has some one studied the advantages and disadvantages of this system?

04 May 2018 900 2 View

Can some strategies be made at the breeding sites of mosquito in inhibiting the life cycle of the malarial parasite in the initial stage ?

As we know that the life cycle of malarial parasite consist of 1. Mosquito 2. Human Drugs available so far interfere with the human portion of the life cycle of the parasite my opinion is that is...

01 February 2018 5,631 4 View

How many volumes a journal can publish in a year ?

What is traditional is that a journal produces 1 volume in a year with: 12 issues if it is a monthly journal. 3 issues if it is a quarterly published journal 2 issues if biannually published Few...

31 December 2017 9,185 7 View

What is the difference between the duration of part time and full time Ph.D in your country ?

In our setup(Pakistan) full time Ph. D duration of study is minimum 3 years while it is 6 years for the part time students as per guide line provided by the official governing body (Pakistan...

31 December 2017 5,756 6 View

What is the time duration for any updated edition of a book to get re-updated again ?

I have gone through many updated editions of different books and found that no fixed time duration is present among them few are published with new edition after 3 years and few after 4 years...

31 December 2017 2,452 0 View

Why the recommendation status fluctuates at RG ?

I observed that the recommendation status keeps on fluctuation for example the number is 108 and after some times it goes to 96 or even 90 and with time its again comes up to 100 plus. What I...

10 November 2017 9,805 0 View

What are the active ingredients of ajwa dates ?

Did some one analyzed the chemical components of ajwa dates ? As many benefits have been described for its use if some one have worked on it kindly share his own experience.

10 November 2017 9,804 4 View

What is the state of the drug inside solid lipid nanoparticles (SLNs)?

I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...

01 March 2021 3,703 3 View

How does an antibody have full intact antibody + half antibody?

Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?

28 February 2021 1,577 1 View

How do I choose contrasts in SPM8?

I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...

24 February 2021 1,534 2 View

I have a problem with kanamycin - why the kanamycin doesn't affect?

Hi everyone, I need to expression of GFP with pET28 plasmid in E. coli BL21(DE3) plysE. Transformed cells have kanamycin and chloramphenicol resistance. Normally, only transformed cells should...

22 February 2021 4,032 4 View

Does anyone have any ideas why drug-resistant malaria is increasing in Southeast Asia even when those drugs are no longer used?

When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...

21 February 2021 6,084 5 View

What is the most prevalent drug related problem in the developed countries?

Detecting the drug related problems is an important step in the pharmaceutical care plan

21 February 2021 5,421 3 View

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19 February 2021 8,647 3 View

How to improve dissolution of neosome?

I have made neosome from herbal drug. Neosomes are stable. But I face problems in dissolution. I used minimum ratio of 1:1:0.25 ( Drug:span 60: Cholesterol and GMs. Now how can I active better...

17 February 2021 3,584 1 View

Can 5-FOA Diffuse Through Agar?

I am preparing to do a gene knockout in the filamentous fungi Coccidioides posadasii targeting pyrG/URA3 so that 5-FOA can be used for selection pressure instead of traditional antibiotic...

16 February 2021 169 4 View

How to determine the drug loading and the drug release capacity of a polymer micelle using UV spectroscopy?

Currently, I am working on PLA-PEG copolymer micelle for the drug delivery system. I have seen several papers where some researcher talks to centrifuge the drug-loaded micelle to separate the...

13 February 2021 5,822 7 View