The senescence-associated secretory phenotype (SASP) is normally a response to DNA damage, but can the SASP occur independent of DNA damage? If not, are cells that have no SASP (or DNA damage) really senescent?
Karl Otto Greulich
There is no cell without DNA damage. Any cell suffer from 10 000 to 60 000 DNA damages per day.
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Harikrishnareddy Paluvai
Your question is highly complex.
It is highly impossible as per my opinion ,because when a cell divides its telomeres become shorter and shorter as number of cell division increases.
When it becomes too short, the cell can no longer divide, and activate DNA damage response to arrest cell growth and enter Senescence stage or apoptosis.
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