Can cellular senescence occur in the absence of DNA damage (but still retain a SASP) in physiological conditions?

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Karl Otto Greulich

There is no cell without DNA damage. Any cell suffer from 10 000 to 60 000 DNA damages per day.

Harikrishnareddy Paluvai

Your question is highly complex.

It is highly impossible as per my opinion ,because when a cell divides its telomeres become shorter and shorter as number of cell division increases.

When it becomes too short, the cell can no longer divide, and activate DNA damage response to arrest cell growth and enter Senescence stage or apoptosis.