What is the mechanism by which phorbol 12-myristate 13-acetate (PMA) induces THP-1 differentiation into macrophages?

I have just started to work with THP-1 monocytes, but cannot seem to find information on the mechanism of PMA on THP-1 for differentiating them into macrophages.  Does anyone know what the...

28 June 2015 9,369 6 View