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I have just started to work with THP-1 monocytes, but cannot seem to find information on the mechanism of PMA on THP-1 for differentiating them into macrophages. Does anyone know what the...
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Following DNA damage and senescence induction it can take up to 7 days (Coppe et al, 2008) for the SASP to fully develop. Since it has been suggested (Burton et al 2010) and evidence provided...
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The senescence-associated secretory phenotype (SASP) is normally a response to DNA damage, but can the SASP occur independent of DNA damage? If not, are cells that have no SASP (or DNA damage)...
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