Dominick G.A Burton

2 Questions 13 Answers 0 Followers

Questions related from Dominick G.A Burton

What is the mechanism by which phorbol 12-myristate 13-acetate (PMA) induces THP-1 differentiation into macrophages?

I have just started to work with THP-1 monocytes, but cannot seem to find information on the mechanism of PMA on THP-1 for differentiating them into macrophages. Does anyone know what the...

28 June 2015 9,409 6 View

Can cellular senescence occur in the absence of DNA damage (but still retain a SASP) in physiological conditions?

The senescence-associated secretory phenotype (SASP) is normally a response to DNA damage, but can the SASP occur independent of DNA damage? If not, are cells that have no SASP (or DNA damage)...

09 December 2013 1,354 2 View