Can be possible the transcription factor's dna binding domain's binding to two or more different DNA sequence in different(or also same) enhancers? Or there is no exception, it must be specific for dna sequence like CAATTAGTCA...
for example my book says; ''MITF's binding domain can attach just the one dna sequence in the different specific enhancers regions. Is there any different possibility?
I think ..
DNA binding site can induce conformational changes in the bound transcription factor.
Check this out..
Article Genome-wide transcription factor binding: Beyond direct targ...
Yes they do. In most cases TF's can bind more than one site with different affinities. Many binding sites share similar binding motifs with slight differences which among many other factor control binding affinity.
Yes they can. Actually if you check Transcription Factor Binding Sites databases, you can often find DNA Binding Transcription Factors that bind multiple DNA motifs (so at least two different DNA sequences). For example the tramtrack protein in Drosophila melanogaster:
http://mccb.umassmed.edu/ffs/TFdetails.php?FlybaseID=FBgn0003870
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