Can anyone say why hydroxypropylbeta cyclodextrin swells more in basic pH than i n acidic?

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Is there any reference showing proliferation of human lymphocyte cells (PBMCs) with increasing dose of any curcumin derivative?

while doing MTT assay in human PBMCs with doses increasing from 25microgm/mL to 100 micro gm/mL, I have found an increasing trend in cell viability. I could not find any reference or the reason...

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How to calculate cumulative drug release ?

I have attached the method as well as calculations for drug release but could not find appropriate results even after several repetitions. It was clearly visible that there must be a high...

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Is there any reference showing gradual dispersion of a drug (especially curcumin derivative) in cell culture media with time?

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Can HPLC be used instead of column chromatography for the purification and isolation of an organic drug molecule?

I have synthesized a drug molecule and now I need to purify and isolate it. Its difficult for me to do column chromatography. So I wanted to know if doing HPLC will serve the purpose or not. Thank...

05 June 2019 6,643 18 View

Can anyone help me analyse the XRD pattern attached?

I have tried to change the structure from CUR to CP. I know XRD is not mandatory here but since I did I would like to analyze the result. A very simple explanation will also be highly appreciated....

03 April 2019 2,624 8 View

Does the MTT assay of a sample show different result if repeated for several times?

If yes how can we compare the effectivity of a newly synthesized sample with the previous ones?

03 April 2017 1,610 0 View

Does sonication leads to breakdown of polymer nano/microparticles?

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Can anyone recommend a polymeric nanoparticle synthesis procedure to load a partially hydrophiic drug to get high loading effeceincy?

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Which one among these is better to write a manuscript: MS Word, Google doc or Latex?

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01 January 1970 8,043 7 View

Separation of organic acids-HPLC?

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07 August 2024 8,782 3 View

How to assess the osmotic power of a substance?

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Determining the worth of a point improvement in Hamilton Depression Scale?

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For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

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Conjugation of PEG-Amine to an Amino Acid Using EDC?

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Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

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30 July 2024 6,420 1 View

How to check pH of a high strength hydrogel?

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Is it possible to use a safer acid instead of monochloroacetic acid to convert bacterial cellulose to carboxymethyl cellulose?

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EDTA buffer solution?

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Whether i can preserve leaves samples in 2.5% glutaraldehyde in 0.05 M phosphate buffer, pH 7 for coming several weeks for further LM study ?

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Nibedita Banik

Bably Khatun You may refer to the below mentioned papers

1. https://www.dovepress.com/development-of-beta-cyclodextrin-based-hydrogel-microparticles-for-sol-peer-reviewed-fulltext-article-DDDT#

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456989/

The explanation is given beautifully there. Hope this will help you.

Bably Khatun

Thank you di Nibedita Banik